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Authors
Affiliations
1 School of Ecology and Conservation and Department of Crop Physiology, University of Agricultural Sciences, GKVK, Bangalore 560 065, IN
2 Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga 577 451, IN
3 University of Agriculture and Horticulture Sciences, Shimoga 577 204, IN
4 Apoptosis and Cell Signalling, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695 014, IN
5 Ashoka Trust for Research in Ecology and the Environment, Royal Enclave, Srirampura, Jakkur PO, Bangalore 560 064, IN
Source
Current Science, Vol 107, No 6 (2014), Pagination: 994-1000
Abstract
Camptothecine (CPT), a monoterpene indole alkaloid, is a potent inhibitor of eukaryotic topoisomerase I. It is produced by a number of plants, including Notha-podytes nimmoniana (Grahm) Mabb. (Icacinaceae), occurring naturally in the Western Ghats, India. The plant is inhabited by a number of endophytic fungi, many of which have been isolated and shown to pro-duce CPT, in culture, independent of the host. In this article, we examine the sensitivity of endophytic fungi isolated from N. nimmoniana to CPT. Contrary to our hypothesis that these fungi should be resistant to CPT (as they are exposed to host CPT as well as that pro-duced by themselves), we report that these fungi are sensitive and thus inhibited by CPT. We discuss these results in the context of the role of CPT in limiting endophytic fungal growth.
Keywords
Camptothecine, Endophytic Fungi, Nothapo-dytes nimmoniana, Sensitivity and Inhibition.
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